A Study of Efficacy of Intraoperative Application of Mitomycin-C in Endoscopic Dacryocystorhinostomy

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Harikesh Sharma
Ajay Mallick

Abstract

Introduction


Common cause for failure of endonasal dacryocystorhinostomy is closure of the intranasal ostium usually due to granulation tissue formation. Attempts have been made to improve the success rate of lacrimal surgery by using different methods like using balloon catheters, lasers and antimetabolites. This study aims to see change in success rate with and without the use of using Mitomycin-C in endonasal Dacryocystorhinostomy (DCR) surgery.


Materials and Methods


Sixty patients of acquired chronic dacryocystitis with nasolacrimal duct blockage, in the age group of 11-50 yrs were taken for study. Patients were alternatively divided into two groups A & B (30 patients in each group). Endoscopic dacryocystorhinostomy with Mitomycin-C application was performed in Group A and without Mitomycin-C application in Group B patients. Subjective assessment for symptomatic improvement and objective analysis obtained from results of syringing. The result data was subjected to Student’s t test and x2analysis.


Result


Age of patients varied from 11 to 50 yrs. The male to female ratio was 7:8 in group A while 2:3 in group B. The commonest age group was between 21 -30 years in both the groups. After 12 month follow up the success rate was 93% in both the groups. The results between the groups were found to be statistically not significant (p>0.05).


Conclusion


Mitomycin C was used in this study to assess its efficacy in improving the results of endoscopic DCR. Mitomycin C did not have significant effect on the outcomes of endoscopic DCR surgery for chronic dacryocystitis.

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1.
Sharma H, Mallick A. A Study of Efficacy of Intraoperative Application of Mitomycin-C in Endoscopic Dacryocystorhinostomy. BJOHNS [Internet]. 2020Jul.27 [cited 2024Nov.21];26(1):29-34. Available from: https://bjohns.in/journal3/index.php/bjohns/article/view/153
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References

Duke-Elder S. Diseases of the lacrimal passages. System of Ophthalmology.London: Henry Kimpton; 1965 p.675-93

Kapadia MK, Freitag SK, Woog JJ. Evaluation and management of congenital nasolacrimal duct obstruction. Otolaryngol Clin N Am. 2006; 39(5):959-77

Mills DM, Meyer DR. Acquired nasolacrimal duct obstruction. Otolaryngol Clin N Am. 2006; 39:979-99

Tanebaum M, McCord CD Jr. The lacrimal drainage system. In: Tasman W, Jaeger EA Editors. Duane’s Clinical Ophthalmology. Philadelphia:Lippincott Raven; 1996. p.4/13/1-31

Bouch GA, Bradlev NL, Dortzbach RK. Results of endonasal laser assisted dacryocystorhinostomy. Ophthalmology 1994; 101:955-9

Kong YT, Kim TI, Byung WK. A report of 131 cases of endoscopic laser lacrimal surgery. Ophthalmology 1994; 101:1793-800

Zilelioglu G, Ugurbas SI, Anadolu Y, Akiner M, Akturk T. Adjunctive use of Mitomycin-C on endoscopic lacrimal surgery. Br J. Ophthalmol. 1998; 82:63-6

Ozkiris M, Ozkiris A, Göktas S. Effect of Mitomycin C on revision endoscopic dacryocystorhinostomy. J Craniofac Surg. 2012; 23(6):e608-10

Singh P, Singh A. Mitomycin-C Use in Ophthalmology. IOSR Journal of Pharmacy 2013; 3(1):12-14

Camara JG, Bengzon AU, Henson RD. The safety and efficacy of Mitomycin-C in endonasal endoscopic laser assisted dacryocystorhinostomy. Ophthal Plast Reconstr Surg. 2000; 16:114-8

Liao SL, Kao SCS, Tseng JHS, Chen MS, Hou PK. Results of intraoperative Mitomycin-C applicartion in dacryocystorhinostomy. Br J Ophthalmol. 2000; 84:903-6

Kao SCS, Liao CL, Tseng JHS, Chen MS et al. Dacryocystorhinostomy with intraoperative Mitomycin-C. Ophthalmology 1997; 104:86-91

Roozitalab MH, Amirahmadi M, Namazi MR. Results of the application of intraoperative Mitomycin-C in dacryocystorhinostomy. Eur J Ophthalmol. 2004; 14:461-3

Ghosh S, Roychoudhury A, Roychaudhuri BK. Use of Mitomycin C in endo-DCR. Indian J Otolaryngol Head Neck Surg. 2006; 58(4):368-9

Welham RA, Wulc AE. Management of unsuccessful lacrimal surgery. Br J Ophthalmol. 1987; 71:152-7.