Primary Thyroid Lymphoma

Main Article Content

Manish Gupta
Ginni Datta
Naiya Rao
Eshita Dadwal

Abstract

Introduction


Lymphoma primarily arising from thyroid gland is very rare. Most patients give a history of previous Hashimoto’s thyroiditis and hypothyroidism.


Case Report


We hereby report one such rare case, who presented with neck swelling and hoarseness. The fine needle aspiration cytology being inconclusive, the patient was taken up for near total thyroidectomy. The histopathology revealed it to be lymphoma, which was further confirmed on immunohistochemistry. The further whole body checkup showed it to be Stage IIE tumor. The patient received chemotherapy for residual mass in neck and is under follow-up for last one year with no recurrence.


Discussion


The case is being presented here due to its rarity, diagnostic dilemma and to discuss the management protocol for same.

Article Details

How to Cite
1.
Gupta M, Datta G, Rao N, Dadwal E. Primary Thyroid Lymphoma. BJOHNS [Internet]. 2020Jul.27 [cited 2024May5];26(2):122-6. Available from: https://bjohns.in/journal3/index.php/bjohns/article/view/182
Section
Case report
Author Biographies

Manish Gupta, Department of ENT, Maharishi Markandeshwar Institute of Medical Science and Research, MMU, Ambala, Haryana, India.

Professor, Department of ENT

1156-C, Govt. Medical College & Hospital Campus,

Sector 32-B, Chandigarh- 160030, India.

Mobile - 09915025819

Email – manishgupta1217@gmail.com

Ginni Datta, Department of ENT, Maharishi Markandeshwar Institute of Medical Science and Research, MMU, Ambala, Haryana, India.

Associate Professor

Naiya Rao, Department of ENT, Maharishi Markandeshwar Institute of Medical Science and Research, MMU, Ambala, Haryana, India.

Junior Resident

Eshita Dadwal, Department of Pathology, Maharishi Markandeshwar Institute of Medical Science and Research, MMU, Ambala, Haryana, India.

Junior Resident, Dept of Pathology

References

Isaacson PG. Lymphoma of the thyroid gland. Curr Top Pathol. 1997; 91:1-14

Kossev P, Livolsi V. Lymphoid lesions of the thyroid: review in light of the revised European- American lymphoma classification and upcoming World Health Organization classification. Thyroid 1999; 9:1273-80

Hwang YC, Kim TY, Kim WB, Shong YK, Yi KH, Shong M, Jo YS, Kim WS, Chung JH. Clinical characteristics of primary thyroid lymphoma in Koreans. Endocrine Journal 2009; 56:399-405

Holm LE, Blomgren H, Lowhagen T. Cancer risks in patients with chronic lymphocytic thyroiditis. N Enl J Med. 1985; 312:601-4

Pedersen RK, Pedersen NT. Primary non-Hodgkin’s lymphoma of the thyroid gland: a population based study. Histopathology 1996; 28:25-32

Yamaguchi M, Ohno T, Kita K. T cell lymphoma of the thyroid gland. N Engl J Med. 1997; 336:1391-2

Stein S A, Wartofsky L. Primary thyroid lymphoma: A clinical review. J Clin Endocrinol Metab. 2013; 98:3131-8

Lam KY, Lo CY, Kwong DLW, Lee J, Srivastava G. Malignant lymphoma of the thyroid: A 30-year clinicopathologic experience and an evaluation of the presence of Epstein-Barr virus. Am J Clin Pathol. 1999; 112:263-70

Matsuzuka F, Miyauchi A, Katayama S, Narabayashi I, Ikeda H, Kuma K, Sugawara M. Clinical aspects of primary thyroid lymphoma: diagnosis and treatment based on our experience of 119 cases. Thyroid 1993; 3:93-9

Cha C, Chen H, Westra WH, Udelsman R. Primary thyroid lymphoma: can the diagnosis be made solely by fine- needle aspiration? Ann Surg Oncol. 2002; 9:298-302

Jeffers MD, Milton J, Herriot R, McKean M. Fine needle aspiration cytology in the investigation on non-Hodgkin’s lymphoma. J Clin Pathol. 1998; 51:189-96

Ota H, Ito Y, Matsuzuka F, et al. Usefulness of ultrasonogrphy for diagnosis of malignant lymphoma of the thyroid. Thyroid 2006; 16:983-7

Carbone PP, Kaplan HS, Musshoff K, Smithers DW, Tubiana M. Report of the committee on Hodgkin’s disease staging classification. Cancer Res. 1971; 31:1860-1

Basu S, Li G, Bural G, Alvi A. Fluorodeoxyglucose positron emission tomography (FDG-PET) and PET/ computed tomography imaging characteristics of thyroid lymphoma and their potential clinical utility. Acta Radiol. 2009; 50:201-4

Logue JP, Hale RJ, Stewart AL, et al. Primary malignant lymphoma of the thyroid: a clinicopathological analysis. Int J Radiat Oncol Biol Phys. 1992; 22:929-33

Thieblemont C, Mayer A, Dumontet C, Barbier Y, Callet-bauchu E, Felman P, Berger F, Ducottet X, Martin C, Salles G, Orgiazzi J, Coiffier B. Primary thyroid lymphoma is a heterogeneous disease. J Clin Endocrinol Metab. 2002; 87(1):105-11.