Addressing Quality of Life Issues in Long Term Survivors of Head & Neck Cancer treated with Radiation Therapy

Main Article Content

Bishan Basu

Abstract

The rapid advancement of curative treatment modalities has resulted in improvement of cure rates of head neck cancer leaving us with a larger number of long term survivors from the disease. Unfortunately, long term complications of therapy continue to hurt patients even after cure, compromising their quality of life. This is particularly true for the patients treated with primary radiation/chemo-radiation therapy, where so called organ preservation does not necessarily translate into preservation of organ function. Long term sequelae of treatment, particularly xerostomia and swallowing difficulties compromise the survivors’ quality of life. More studies, particularly suited to our clinical scenario, are warranted to address the quality of life issues in these patients, so that better evidence-based guidelines may be developed for their benefit.

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1.
Basu B. Addressing Quality of Life Issues in Long Term Survivors of Head & Neck Cancer treated with Radiation Therapy. BJOHNS [Internet]. 2015Apr.4 [cited 2024Nov.21];23(1):18-25. Available from: https://bjohns.in/journal3/index.php/bjohns/article/view/32
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Invited article

References

Available at: http://www.who.int/mental_health/media/68.pdf ; accessed 21st December, 2014

Boyle P et al. World Cancer Report 2008. International Agency for Research on Cancer.

Chaturvedi P. Head and Neck Surgery; J Can Res Ther 2009: 5: 143

Kulkarni M R : Head and Neck Cancer Burden in India; Int J Head Neck Sur; Jan-Apr (2013); 4(1); 29-35

Yeole BB, Sankaranarayanan R, Sunny M Sc L, Swaminathan R, Parkin DM.; Survival from head and neck cancer in Mumbai (Bombay), India. Cancer. 2000 Jul 15;89(2):437-44.

Pignon JP, le Maitre A, Bourhis J; Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update: Int J Radiat Oncol Biol Phy 2007;69(2 Suppl):S112-14

Martino R; Evaluation of Quality of Life and organ function in head and neck squamous cell carcinoma; Hematol Oncol Clin N Am; 22 (2008); 1239-1256

Trotti A, Pajak TF, Gwede CK et al; TAME : development of a new method for summarizing adverse effects of cancer treatment by the Radiation Therapy Oncology Group.; Lancet Oncol 2007; 8(7); 613-24

Chandu A, Smith AC, Rogers SN; Health-related Quality of Life in Oral Cancer : a review; J Oral Maxillofac Sur 2006; 64(3); 495-502

Nguyen NP, Sallah S,Karlsson U. et al; Combined chemotherapy and radiation therapy for head and neck malignancies: quality of life issues; Cancer 2002; 94(4); 1131-1141

De Conno F, Sbanotto A, Ripamonti C et. al.; Chapter 8.12 Mouth Care in Oxford Textbook of Palliative Medicine, 3rd Edition; Ed : Doyle D, Hanks G, Cherny NI, Calman K; Oxford University Press 2004

Makkonen, T.A. et al. Changes in the protein composition of whole saliva during radiotherapy in patients with oral or pharyngeal cancer. Oral Surgery 1986 62, 270-5.

Johnson JT, Ferretti GA, Nethery WJ et. al.; Oral Pilocarpine for post-irradiation xerostomia in patients with head and neck cancer. N Engl J Med 1993; 329(6): 390-5

Eisbruch A, Kim HM, Terrell JE et al. Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer. Int J of Radiat Oncol Biol Phys 2001 50(3); 695-704.

Cannon DM, Lee NY; Recurrence in region of spared parotid gland after definitive intensity-modulated radiotherapy for head and neck cancer: Int J Radiat Biol Oncol Phys 2008; 70(3): 660-5

Brizel DM, Wasserman TH, Henke M et al. Phase III randomized trial of amifostine as a radioprotectant in head and neck cancer; J Clin Oncol 2000; 18 (19): 3339-45

Wasserman TH, Brizel DM, Henke M et.al.; Influence of intravenous amifostine on xerostomia, tumor control, and survival after radiotherapy for head-and-neck cancer: 2 year follow-up of a prospective, randomized, phase III trial. Int J Radiat Biol Oncol Phys 2005; 63(4): 985-90

Jha N, Sekaly H, McGaw T et. al.; Submandibular salivary gland transfer prevents radiation-induced xerostomia; Int J Radiat Oncol Biol Phys 2000; 46(1); 7-11

Seikaly H, Jha N, Harris JR et. al.: Long-term outcomes of submandibular gland transfer for prevention of post-radiation xerostomia; Arch Otolaryngol Head Neck Surg 2004; 130(8); 956-61

Seikaly, H. et al.. Submandibular gland transfer: a new method of preventing radiation-induced xerostomia. Laryngoscope 2001; 111 (2), 347-52

Jha N, Seikaly H, Harris J et. al.; Prevention of radiation induced xerostomia by surgical transfer of submandibular salivary gland into the submental space; Radiother Oncol 2003; 66(3); 283-9

Schuller, D.E. et al.; Treatment of radiation side-effects with oral pilocarpine. J Surg Oncol 1989; 42; 272-6.

Greenspan D, Daniels T.E.; Effectiveness of pilocarpine in postradiation xerostomia. Cancer 1987; 59, 1123-5.

LeVeque, F.G. et al.. A multicenter, randomized, double-blind, placebo-controlled, dose-titration study of oral pilocarpine for treatment of radiation-induced xerostomia in head and neck cancer patients. J Clin Oncol 1993; 11; 1124-31.

Johnson, J.T. et al. Oral pilocarpine for post-irradiation xerostomia in patients with head and neck cancer. N Engl J Med 1993; 329; 390-5.

Rieke, J.W. et al. Oral pilocarpine for radiation-induced xerostomia: integrated efficacy and safety results from two prospective randomized clinical trials. Int J Radiat Oncol Biol Phys 1995; 31; 661-9.

Horiot, J.C. et al.; Post-radiation severe xerostomia relieved by pilocarpine: a prospective French cooperative study. Radiother Oncol 2000; 55 (3), 233-9.

Logemann JA, Pauloski BR, Rademaker AW, et al. Xerostomia: 12-month changes in saliva production and its relationship to perception and performance of swallow function, oral intake, and diet after chemoradiation. Head Neck 2003; 25(6):432–7.

Nguyen NP, Frank C, Moltz CC, et al. Aspiration rate following chemoradiation for head and neck cancer: an underreported occurrence. Radiother Oncol 2006;80(3):302–6.

Dowling E.R., Murphy B., Cmelak, A.. Swallowing deficits in patients treated with combined chemoradiation for locally advanced head and neck cancer; Proceedings of the American Society of Clinical Oncology 2001; 20; 227a.

Kendall K.A.; Structural mobility in deglutition after single modality treatment of head and neck carcinomas with radiotherapy. Head & Neck 1998; 20; 720-5.

Chen AY, Frankowski R, Bishop-Leone J, et al. The development and validation of a dysphagia-specific quality-of-life questionnaire for patients with head and neck cancer: the M.D. Anderson dysphagia inventory. Arch Otolaryngol Head Neck Surg 2001;127(7):870–6.

McHorney CA, Bricker DE, Kramer AE, et al. The SWAL-QOL outcomes tool for oropharyngeal dysphagia in adults: I. Conceptual foundation and item development. Dysphagia 2000;15(3):115–21.

McHorney CA, Bricker DE, Robbins J, et al. The SWAL-QOL outcomes tool for oropharyngeal dysphagia in adults: II. Item reduction and preliminary scaling. Dysphagia 2000;15(3):122–33.

McHorney CA, Robbins J, Lomax K, et al. The SWAL-QOL and SWAL-CARE outcomes tool for oropharyngeal dysphagia in adults: III. Documentation of reliability and validity. Dysphagia 2002;17(2):97–114.

Curran D, Giralt J, Harari PM, et al. Quality of life in head and neck cancer patients after treatment with high-dose radiotherapy alone or in combination with cetuximab. J Clin Oncol 2007;25(16):2191–7.

Ringash J, Lockwood G, O’Sullivan B, et al. Hyperfractionated, accelerated radiotherapy for locally advanced head and neck cancer: quality of life in a prospective phase I/II trial. Radiother Oncol 2008;87(2):181–7.

Mehanna HM, Morton RP. Deterioration in quality-of-life of late (10-year) survivors of head and neck cancer. Clin Otolaryngol 2006;31(3):204–11.

Bjordal K, Ahlner-Elmqvist M, Hammerlid E, et al. A prospective study of quality of life in head and neck cancer patients, part II: longitudinal data. Laryngoscope. 2001;111(8):1440-1452

Hammerlid E, Ahlner-Elmqvist M, Bjordal K, et al. A prospective multicentre study in Sweden and Norway of mental distress and psychiatric morbidity in head and neck cancer patients. Br J Cancer. 1999;80(5-6):766-774

Hammerlid E, Silander E, Hörnestam L, Sullivan M. Health-related quality of life three years after diagnosis of head and neck cancer—a longitudinal study. Head Neck. 2001;23(2):113-125

Hammerlid E, Taft C. Health-related quality of life in long-term head and neck cancer survivors: a comparison with general population norms. Br J Cancer. 2001;84(2):149-156

Abendstein H, Nordgren M, Boysen M, et al. Quality of life and head and neck cancer: a 5 year prospective study. Laryngoscope. 2005;115(12):2183-2192

Nordgren M, Abendstein H, Jannert M, et al. Health-related quality of life five years after diagnosis of laryngeal carcinoma. Int J Radiat Oncol Biol Phys. 2003;56(5):1333-1343

Nordgren M, Jannert M, Boysen M, et al. Health-related quality of life in patients with pharyngeal carcinoma: a five-year follow-up. Head Neck. 2006;28(4):339-349

Bjordal K, Kaasa S, Mastekaasa A. Quality of life in patients treated for head and neck cancer: a follow-up study 7 to 11 years after radiotherapy. Int J Radiat Oncol Biol Phys. 1994;28(4):847-856

Bjordal K, Mastekaasa A, Kaasa S. Self-reported satisfaction with life and physical health in long-term cancer survivors and a matched control group. Eur J Cancer B Oral Oncol. 1995;31B(5):340-345

Bjordal K, Kaasa S. Psychological distress in head and neck cancer patients 7-11 years after curative treatment. Br J Cancer. 1995;71(3):592-597

Earle CC. Cancer survivorship research and guidelines: maybe the cart should be beside the horse. J Clin Oncol. 2007;25(25):3800-3801

Institute of Medicine: From cancer patient to cancer survivor: Lost in transition. Washington, DC, National Academies Press, 2005

Rogers SN, Ahad SA, Murphy AP. A structured review and theme analysis of papers published on ‘quality of life’ in head and neck cancer: 2000–2005. Oral Oncol 2007;43(9):843–68.

Lipscomb J, Gotay CC, Snyder CF. Patient-reported outcomes in cancer: a review of recent research and policy initiatives. CA Cancer J Clin 2007; 57(5):278–300.

Lipscomb J, Reeve BB, Clauser SB, et al. Patient-reported outcomes assessment in cancer trials: taking stock, moving forward. J Clin Oncol 2007;25(32):5133–40.

Murphy BA, Ridner SH, Wells N, et al. Quality of life research in head and neck cancer: a review of the current state of the science. Crit Rev Oncol Hematol 2007;62(3):251–67.