Juvenile Nasopharyngeal Angiofibroma: Changing Paradigms in Management
Main Article Content
Abstract
Introduction
Juvenile Nasopharyngeal Angiofibroma (JNA) is a tumor of young and adolescent males. It is a benign vascular tumor arising from the spheno-palatine foramen. It is best managed surgically at present by endoscopic methods with or without pre-operative embolization. Tumor attributes like intracranial extent and residual vascularity after embolization need to be assessed pre-operatively before undertaking endoscopic surgery, in order to reduce surgical blood loss and morbidity.
Materials and Methods
Twenty-three cases of JNA (n=23) were operated endoscopically at a tertiary level military hospital. They were staged with the Snyderman staging system. Demographic variables including stage wise management were brought out with intraoperative time and blood loss recorded for different stages.
Results
The intraoperative surgical time, intra-operative blood loss and recurrence/residual rates were compared with similar studies in existing literature and correlated well.
Conclusion
Endoscopic Endonasal approach to JNA is now a well-established technique. With improvements in embolization techniques and better instrumentation like HD camera systems, endo-bipolar cautery, Coblation and endo-liga clips and neuro-navigation, better visualization and better haemostatis can be achieved, resulting in significant reduction in the morbidity and improvement in surgical results.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
References
Andrade NA, Pinto JA, Nóbrega MO. Exclusively endoscopic surgery for juvenile nasopharyngeal angiofibroma. Otolaryngol Head Neck Surg. 2007; 137:492-6
Lutz J, Holtmannspötter M, Flatz W. Preoperative Embolization to Improve the Surgical Management and Outcome of Juvenile Nasopharyngeal Angiofibroma (JNA) in a Single Center: 10-Year Experience; Clin Neuroradiol. (2016) 26: 405
Lund VJ, Stammberger H, Nicolai P. European position paper on endoscopic management of tumours of the nose, paranasal sinuses and skull base. Rhinol Suppl. 2010; 22:1-143
Snyderman CH, Pant H, Carrau RL, Gardner P. A new endoscopic staging system for angiofibromas. Arch Otolaryngol Head Neck Surg. 2010; 136:588-94
Mann WJ, Jecker P, Amedee RG. Juvenile angiofibromas: changing surgical concept over the last 20 years. Laryngoscope 2004; 114:291-3
Andrews JC, Fisch U, Valavanis A, Aeppli. The surgical management of extensive nasopharyngeal angiofibromas with the infratemporal fossa approach. Laryngoscope 1989; 99:429-37
Radkowski D, McGill T, Healy GB. Angiofibroma- Changes in staging and treatment. Arch Otolaryngol Head Neck Surg. 1996; 122(2): 122-9
Howard DJ, Lloyd G, Lund V. Recurrence and its avoidance in juvenile angiofibroma. Laryngoscope. 2001; 111(9): 1509-11
Lloyd G, Howard D, Phelps P, et al. Juvenile angiofibroma: the lessons of 20 years of modern imaging. Journal of Laryngology and Otology 1999; 113(2):127-34
Danesi G, Panciera DT, Harvey RJ. Juvenile nasopharyngeal angiofibroma: evaluation and surgical management of advanced disease. Otolaryngology—Head and Neck Surgery 2008; 138(5):581-6
Wu AW, Mowry SE, Vinuela F. Bilateral vascular supply in juvenile nasopharyngeal angiofibromas. Laryngoscope 2011; 121(3):639-43
Scholtz AW, Appenroth E, Kammen-Jolly K. Juvenile nasopharyngeal angiofibroma: management and therapy. Laryngoscope 2001;111(4): 681-7
Yiotakis I, Eleftheriadou A, Davilis D. Juvenile nasopharyngeal angiofibroma stages I and II: a comparative study of surgical approaches. International Journal of Pediatric Otorhinolaryngology 2008; 72(6):793-800
Mitskavich MT, Carrau RL, Snyderman CH. Intranasal endoscopic excision of a juvenile angiofibroma. Auris Nasus Larynx 1998; 25(1): 39-44
Snyderman CH, Pant H. Endoscopic Management of Vascular Sinonasal Tumors, Including Angiofibroma. Otolaryngol Clin of North Am. 2016;49 (3):791-807
Hackman T, Snyderman CH, Carrau R, Kassam A. Juvenile nasopharyngeal
angiofibroma: The expanded endonasal approach.Am J Rhinol Allergy. 2009; 23(1):95-9
Rowan NR, Zwagerman NT, Heft-Neal ME. Juvenile Nasal Angiofibromas: A Comparison of Modern Staging Systems in an Endoscopic Era. J Neurol Surg B Skull Base 2017; 78 (1): 63-7
Borota L, Mahmoud E, Nyberg C. Combined percutaneous and transarterial devascularisation of juvenile nasopharyngeal angiofibroma with protection of internal carotid artery: A modification of the technique. Interv Neuroradiol. 2015; 21(3): 390-6
Nicolai P, Villaret AB, Farina D. Endoscopic surgery for juvenile angiofibroma: a critical review of indications after 46 cases. American Journal of Rhinology and Allergy 2010; 24(2):e67–e72
Makek MS, Andrews JC, Fisch U. Malignant transformation of a nasopharyngeal angiofibroma. Laryngoscope 1989; 99(10):1088-92
Thakar A, Gupta G, Bhalla AS. Adjuvant therapy with flutamide for presurgical volume reduction in juvenile nasopharyngeal angiofibroma. Head and Neck 2011; 33(12):1747-53
Ardehali MM, Samimi Ardestani SH, Yazdani N, Goodarzi H, Bastaninejad S. Endoscopic approach for excision of juvenile nasopharyngeal angiofibroma: complications and outcomes. Am J Otolaryngol. 2010; 31(5):343–9
Roger G, Tran Ba Huy P, Froehlich P, Van Den Abbeele T, Klossek JM, Serrano E, et al. Exclusively endoscopic removal of juvenile nasopharyngeal angiofibroma: trends and limits. Arch Otolaryngol Head Neck Surg. 2002; 128(8):928-35
Pryor SG, Moore EJ, Kasperbauer JL. Endoscopic versus traditional approaches for excision of juvenile nasopharyngeal angiofibroma. Laryngoscope 2005; 115(7):1201-7
Kopeć T, Borucki Ł, Szyfter W. Fully endoscopic resection of juvenile nasopharyngeal angiofibroma - own experience and clinical outcomes. Int J Pediatr Otorhinolaryngol. 2014; 78(7):1015-8
Cloutier T, Pons Y, Blancal JP, Sauvaget E, Kania R, Bresson D et al. Juvenile nasopharyngeal angiofibroma: does the external approach still make sense? Otolaryngol Head and Neck Surg. 2012; 147 (5): 958-63.