Synchronous Buccal Carcinoma and Laryngeal Carcinoma- A Rare Presentation
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Abstract
Introduction
Second primary malignancy as squamous cell carcinoma of larynx is rare after squamous cell carcinoma of buccal mucosa.
Case Report
A 47 year old male patient presented with a painless, progressive ulcer of left buccal mucosa near the angle of mouth for the last 3 months who also developed alteration in the quality of voice and respiratory distress 2 months later. On biopsy buccal lesion came out to be moderately differentiated squamous cell carcinoma. Direct laryngoscopy revealed a glottic growth and guided biopsy from the lesion revealed well differentiated keratinising squamous cell carcinoma which was managed successfully by total laryngectomy and buccal carcinoma by wide local excision followed by primary closure and supraomohyoid neck dissection in the same sitting.
Discussion
Having both index primary tumour and second primary tumour in head and neck region is a rare occurrence more so glottic carcinoma occurring synchronously with buccal carcinomas. Surgery is the mainstay of treatment in both the conditions.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
References
Chaturvedi A K, Anderson W F, Lortet-Tieulent J, Curado M P, Ferlay J, Franceschi S, Rosenberg P S, Bray F, and Gillison M L. Worldwide Trends in Incidence Rates for Oral Cavity and Oropharyngeal Cancers. J Clin Oncol. 2013; 31(36):4550-4559
Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun M J. Cancer statistics. CA Cancer J Clin.2007;57(1):43-66
Vigneswaran N, Michelle D. Williams. Epidemiological Trends in Head and Neck Cancer and Aids in Diagnosis. Oral Maxillofac Surg Clin North Am. 2014; 26(2): 123-41
Lambert R, Sauvaget C, de Camargo Cancela M, Sankaranarayanan R. Epidemiology of cancer from the oral cavity and oropharynx. Eur J Gastroenterol Hepatol. 2011; 23:633
Mehdi I, Shah AH, Moona MS, et al. Synchronous and metachronous malignant tumours expect the unexpected. J Pak Med Assoc. 2010; 60(11):905-9
Morris L G, Sikora A Gg, Patel S G, Hayes R B, Ganly I. Second primary cancers after an index head and neck cancer: subsite- specific trends in the era of human papillomavirus-associated oropharyngeal cancer. J. Clin.Oncol.2011; 29(6):739-46
Krishnatreya M, Rahman T, Kataki A C, Das A, Das A K, Lahkar K. Synchronous primary cancers of the head and neck region and upper aero digestive tract: Defining high-risk patients. Indian J Cancer 2013;50:322-6
Warren S, Gates O. Multiple primary malignant tumours: A survey of the literature and statistical study. Am J. Cancer.1932; 16:1358-414
Bagri P K, Singh D, Bardia M R. Double Primary Malignancies: A Clinical & Pathological Analysis Report from Regional Cancer Institute in India.Iran J Cancer Prev. 2014 Spring7(2)
Slaughter D P, Southwick H W, Smejkal W. Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 1953; 6(5):963-8
Diaz E M Jr, Holsinger F Cc, Zungia E R, et al. Squamous cell carcinoma of the buccal mucosa: one institution’s experience with 119 previously untreated patients. Head Neck. 2003; Apr. 25(4):267-73
Chhetri D K, Rawnsley J D, Calcaterra T C. Carcinoma of the buccal mucosa. Otolaryngol Head Neck Surg. 2000; 123(5):566-71
Min SK, Choi SW, Lim J, Park JY, Jung KW, Won YJ. Second primary cancers in patients with oral cavity cancer included in the Korea Central Cancer Registry. Oral Oncol. 2019; 95:16-28. doi:10.1016/j.oraloncology.2019.05.025
Sassi L M, Cervantes O, Schussel J L, Stramandinoli R T, Guebur M I, Ramos G H A. Incidence of second primary oral cancer tumours: a retrospective study. Rev. Oconto ciênc. 2010; 25(4):367-70
Rajani B C, Hoda N , Dikhit P S, Roy S. Incidence of Second Primary Tumor in Patients with Oral Squamous Cell Carcinoma: Experience from a Tertiary Cancer Centre. IOSR Journal of Dental and Medical Sciences. (IOSR-JDMS) 2019; 18(8):72-4
Ghosh D, Sannigrahi R, Basu S K, Basu P. Synchronous squamous cell carcinoma of external acoustic meatus following pigmented basal cell carcinoma of cheek -a rare occurrence. Bengal Journal of Otolaryngology and Head Neck Surgery 2015; 23(3):123-8.