Alteration in Status of Olfaction amongst COVID 19 Patients: A Descriptive Study in a Dedicated COVID Hospital of Eastern India

Main Article Content

Monoj Mukherjee
Anupam Ray
Arpita Mohanty
Sekhar Ranjan Paul

Abstract

Introduction


COVID 19 patients present with symptoms of respiratory tract infection as it is caused by SARS Cov-2 which is a β corona virus. A significant number of patients may complain of changes in olfaction either at the onset or later. The incidence, severity and recovery from anosmia/hyposmia varies in different patients. This study was done to investigate the effect of COVID 19 on olfactory dysfunction in the Indian population.


Materials & Methods


100 patients admitted with RT-PCR positive reports for SARS Cov-2, in a dedicated COVID hospital in eastern India, were included in this study. Their olfactory function was estimated by pocket smell test (4 items) during ENT examination at bed side. Recovery from anosmia/hyposmia were noted during follow up visits.


Results


In our study 36% of patients had some alteration in smell.  Out of the 36%, 12% had anosmia and 24% had hyposmia. Chances of complete recovery is more in patients suffering from anosmia than hyposmia.


Conclusion


Changes in smell sensation is a significant marker for screening and diagnosis of cases of COVID 19. Most of the patients recover completely.

Article Details

How to Cite
1.
Mukherjee M, Ray A, Mohanty A, Paul S. Alteration in Status of Olfaction amongst COVID 19 Patients: A Descriptive Study in a Dedicated COVID Hospital of Eastern India. BJOHNS [Internet]. 2021Feb.11 [cited 2024May15];28(3):241-7. Available from: https://bjohns.in/journal3/index.php/bjohns/article/view/375
Section
Main article
Author Biographies

Monoj Mukherjee, Nil Ratan Sircar Medical College

Associate Professor, Department of ENT

Anupam Ray, Nil Ratan Sircar Medical College

Assistant Professor, Department of ENT

Sekhar Ranjan Paul, Infectious Disease and Beleghata General Hospital

Senior Resident, Department of General Medicine

References

REFERENCES:

Wu YC, Chen CS, Chan YJ. Overview of The 2019 Novel Coronavirus (2019-nCoV): The Pathogen of Severe Specific Contagious Pneumonia (SSCP). J Chin Med Assoc. 2020. doi: 10.1097/JCMA.0000000000000270.

Huang C,Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506doi:10.1016/S0140-6736(20)30183-5

Xydakis MS, Mulligan LP, Smith AB, et al. Olfactory impairment and traumatic brain injury in blast-injured combat troops: a cohort study. Neurology 2015; 84: 1559–67.

Xydakis MS, Belluscio L. Detection of neurodegenerative disease using olfaction. Lancet Neurology 2017; 16: 415–16.

Suzuki M, Saito K, Min WP, Vladau C, Toida K, Itoh H, Murakami S. Identification of viruses in patients with postviral olfactory dysfunction. Laryngoscope. 2007; 117(2):272-7.

Van Riel D, Verdijk R, Kuiken T. The olfactory nerve: a shortcut for influenza and other viral diseases into the central nervous system. J Pathol. 2015; 235(2):277-87. doi: 10.1002/path.4461.

Jerome R. Lechien et al,Olfactory and Gustatory Dysfunctions as a Clinical Presentation of Mild to Moderate forms of the Coronavirus Disease (COVID-19): A Multicenter European Study, Email: Jerome.Lechien@umons.ac.be

Jan C. Luers , MD; Alexander C. Rokohl , MD; NiklasLoreck; Philomena A. Wawer Matos; Max Augustin ; Felix Dewald, MD; Florian Klein, MD; Clara Lehmann MD; Ludwig M. Heindl , MD, Olfactory and Gustatory Dysfunction in Coronavirus Disease 19 (COVID-19), Oxford University Press for the Infectious Diseases Society of America, 2020.

Smell and Taste Disorders: Diagnosis - Medical Clinical Policy Bulletins | Aetna.

Seiden AM, Duncan HJ. The diagnosis of a conductive olfactory loss. Laryngoscope. 2001;111(1):9-14. doi:10.1097/00005537-200101000-00002.

Lovato A, de Filippis C. Clinical presentation of COVID-19: a systematic review focusing on upper airway symptoms. Ear Nose Throat J 2020. https://doi.org/10.1177/0145561320920762. [145561320920762, Apr 13. [Epub ahead of print]].

Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020. https://doi.org/10.1001/jamaneurol.2020.1127. [Apr 10. [Epub ahead of print]]

Pragyanshu Khare1, Atul Munish Chander1 et al , Utility of Olfactory test as screening tool for COVID-19: A pilot Study; medRxiv preprint doi: https://doi.org/10.1101/2020.09.03.20187294

Prasun Mishra, Vishwanath Gowda et ,Prevalence of New Onset Anosmia in COVID-19 Patients: Is The Trend Different Between European and Indian Population? al Indian J Otolaryngol Head Neck Surg ,https://doi.org/10.1007/s12070-020-01986-8.

Li YC, BaiWZ, Hashikawa T. The neuroinvasive potential of SARS-CoV-2 may play a role in the respiratory failure of COVID-19 patients [published online,February 27, 2020]. J Med Virol. doi:10.1002/jmv.25728.

Yao L, Yi X, Pinto JM, et al. Olfactory cortex and olfactory bulb volume alterations in patients with post-infectious olfactory loss. Brain Imaging Behav.2018;12(5):1355-1362. doi:10.1007/s11682-017-9807-7

An SS, Liggett SB. Taste and smell GPCRs in the lung: evidence for a previously unrecognized widespread chemosensory system. Cell Signal. 2018;41:82-88. doi:10.1016/j.cellsig.2017.02.002.

Leon Fodoulin, Joel Tuberosa , Daniel Rossier, et al,SARS- CoV-2 receptor and entry genes areexpressed by sustentacular cells in human olfactory neuroepithelium, https://doi.org/10.1101/2020.03.31.013268.