Rhino-Orbital-Cerebral Mucormycosis: Clinico-Epidemiologic Study in a Regional Centre in Eastern India during the Second Wave of COVID-19 Pandemic

Main Article Content

Titli Bandyopadhyay
Monoj Mukherjee
Arvind Kumar Verma
V D Prasanna Kumar Vasamsetty
Satish Reddy Satty

Abstract

Introduction


Rhino-orbital -cerebral mucormycosis (ROCM), a life-threatening acute fungal rhinosinusitis, has recently been reported in increasing numbers in post-COVID patients in the backdrop of uncontrolled hyperglycemia. We present our on-going experience with these patients.


Materials and Methods


A descriptive longitudinal study involving forty-three ROCM patients, during the 2nd wave of COVID -19, are presented here to discuss the epidemiology, clinical features, management approaches and outcomes.


Results


Commoner in males (65%), most ROCM patients belonged to lower socio-economic status and 41-50 years age group. Eighty six percent patients were known diabetics and confirmed COVID-19 illness were present in and 53% patients. Advanced disease (Stage-3&4) was found in 54% of patients at presentation. Diagnosis was confirmed by fungal culture and histopathological evidence of tissue invasion.   All patients received injection Amphotericin B and undergone surgical debridement (endoscopic or external approach). Seventy two percent patients were discharged on oral antifungal post -debridement, 28% patients expired during course of treatment.


Conclusion


ROCM led to significant morbidity and mortality in post COVID patients due to its aggressive nature, late presentation and limited guidelines on management protocol. Early diagnosis in patients presented with suggestive background and a multidisciplinary team management approach is crucial.  Randomized control trials on efficacy of various treatment modalities with duration of antifungal treatment will help in better management of these patients.

Article Details

How to Cite
1.
Bandyopadhyay T, Mukherjee M, Verma AK, Vasamsetty VDPK, Reddy Satty S. Rhino-Orbital-Cerebral Mucormycosis: Clinico-Epidemiologic Study in a Regional Centre in Eastern India during the Second Wave of COVID-19 Pandemic. BJOHNS [Internet]. 2022Dec.3 [cited 2024Nov.5];30(1):21-8. Available from: https://bjohns.in/journal3/index.php/bjohns/article/view/595
Section
Main article
Author Biographies

Titli Bandyopadhyay, a:1:{s:5:"en_US";s:46:"Bankura Sammilani Medical College and Hospital";}

Clinical tutor,Department of ENT

Monoj Mukherjee, Bankura Sammilani Medical College and Hospital

Additional professor, department of ENT,

Arvind Kumar Verma, Bankura Sammilani Medical College and Hospital

Assistant professor, Department of ENT

V D Prasanna Kumar Vasamsetty, Bankura Sammilani Medical College and Hospital

Senior resident, Department of ENT

Satish Reddy Satty, Bankura Sammilani Medical College and Hospital

Senior resident, Department of ENT

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