Surgical Approach to Rhino-Orbital Mucormycosis using Contrast Enhanced MRI as Roadmap

Main Article Content

Titas Kar
Arya Brata Dubey
Subhradev Biswas

Abstract

Introduction


Increase in Mucormycosis cases following COVID-19 infection was major concern due to angio-invasive nature causing necrosis. Aggressive surgical resection is necessary to combat this infection. Identifying areas of involvement like orbit, infratemporal fossa and nature of involvement (enhancing or non-enhancing) is best assessed by MRI. Hence, we decided to use MRI as surgical roadmap for disease clearance.


 


Materials and Methods


 


All post-COVID suspected mucormycosis cases based on clinical suspicion underwent MRI and nasal endoscopic biopsy. In MRI we evaluated T1 with contrast and T2 with fat suppression. Once Mucormycosis was confirmed by biopsy, Amphotericin B was started with monitoring of biochemical parameters. Surgical resection till level of viable tissue was reached was done based on MRI findings. Post-operatively patients underwent nasal douching and endoscopic surveillance.


 


Results


 


Our surgical experience shows that maximum patients had to undergo unilateral FESS with modified endoscopic Denker’s approach and opening of pterygopalatine and infratemporal fossa. We conclude that all patients must minimally undergo the above surgery. Endoscopic Denker’s approach allows easy post-operative surveillance. The pterygopalatine and infratemporal fossa is anatomically hidden by posterior wall of maxilla. Since we found more than 50% involvement of these areas, the necessity to open and visualise the areas in our opinion is must in all cases of post-COVID rhino-orbital mucormycosis.


 


Conclusion


Post-COVID Rhino-Orbital Mucormycosis requires high index of suspicion. Underrated symptoms like headache, facial pain and facial swelling in post-COVID patients with associated immunocompromised state like diabetes mellitus must be thoroughly investigated by MRI nose, paranasal sinus and orbit. Surgical debridement as dictated by MRI and routine inspection of pterygopalatine and infratemporal fossa should be done.

Article Details

How to Cite
1.
Kar T, Dubey AB, Biswas S. Surgical Approach to Rhino-Orbital Mucormycosis using Contrast Enhanced MRI as Roadmap: . BJOHNS [Internet]. 2022Dec.3 [cited 2024Nov.5];30(1):95-103. Available from: https://bjohns.in/journal3/index.php/bjohns/article/view/608
Section
Main article
Author Biographies

Titas Kar, IPGMER &SSKM Hospital, 244, A.J.C. Bose Road, Kolkata 700020

Senior Resident,

Institute of Otorhinolaryngology & Head Neck Surgery

 

Arya Brata Dubey, IPGMER &SSKM Hospital, 244, A.J.C. Bose Road, Kolkata 700020

RMO cum Clinical tutor

Institute of Otorhinolaryngology & Head Neck Surgery.

Subhradev Biswas, IPGMER &SSKM Hospital, 244, A.J.C. Bose Road, Kolkata 700020

Associate Professor,

Institute of Otorhinolaryngology & Head Neck Surgery.

References

Kubin CJ, McConville TH, Dietz D, et al. Characterization of Bacterial and

Fungal Infections in Hospitalized Patients with COVID-19 and Factors Associated

with Healthcare-associated Infections, Open Forum Infectious Diseases, 2021;

ofab201, https://doi.org/10.1093/ofid/ofab201

Rootman J, Robertson W, Lapointe JS. Inflammatory diseases. In: Rootman J, editor. Diseases of the Orbit. A Multidisciplinary Approach. 1st ed. J. B. Lippincott Company; 1988; p. 155‑6

Song G, Liang G, Liu W. Fungal co‑infections associated with global COVID‑19 pandemic: A clinical and diagnostic perspective from China. Mycopathologia 2020; 185:599‑606

Singh AK, Singh R, Joshi SR, Misra A, Mucormycosis in COVID-19: A systematic review of cases reported worldwide and in India, Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2021; doi: https://doi.org/10.1016/j.dsx.2021.05.019

Spellberg B, Edwards J, Ibrahim A. Novel perspectives on Mucormycosis: pathophysiology, presentation, and management. Clin Microbiol Rev 2005;18:556-69

Boelaert JR. Mucormycosis (zygomycosis): is there news for the clinician. J Infect. 1994; 28:1-6

Gupta M, Bakshi R, Gupta J. Rhinocerebral Mucormycosis: the disease spectrum in 27 patients. Mycoses 2007; 50:290-6

Sugar AM. Mucormycosis. Clin Infect 1992; 14:126-9

Jiang RS, Hsu CY. Endoscopic sinus surgery for rhinocerebral Mucormycosis. Am J Rhinol. 1999; 13:105-9

Avet PP, Kline LB, Sillers MJ. Endoscopic sinus surgery in the management of Mucormycosis. J Neuroophthalmol. 1999; 19:56-61

Ravani SA, Agrawal GA, Leuva PA, Modi PH, Amin KD. Rise of the phoenix: Mucormycosis in COVID-19 times. Indian J Ophthalmol. 2021; 69:1563-8

Safder S, Carpenter JS, Roberts TD, Bailey N. The Black Turbinate” sign: An early imaging finding of Nasal Mucormycosis, Am J Neuroradiol. April 2010. 31:771-74

Herrera DA, Dublin AB, Ormsby EL, Aminpour S, Howell LP. Imaging findings of rhinocerebral mucormycosis. Skull Base. 2009;19(2):117-25. doi: 10.1055/s-0028-1096209

Mathur S, Karimi A, Mafee MF. Acute optic nerve infarction demonstrated by diffusion weight imaging in case of rhino-cerebral Mucormycosis. AJNR Am J Neuroradiol. 2007; 28:489-90

Awal SS, Biswas SS, Awal SK, Rhino-orbital Mucormycosis in COVID-19 patients- a new threat?. Egyptian Journal of Audiology and Nuclear Medicine. 52(1):1. doi: 10.1186/s43055-021-00535-9

Malleshappa V, Rupa V, Varghese L, Kurien R. Avoiding repeated surgery in patients with acute invasive fungal sinusitis. European Archives of Oto-Rhino-Laryngology https://doi.org/10.1007/s00405-020-05879-y

Saedi B, Sadeghi M, Seilani P. Endoscopic management of rhinocerebral Mucormycosis with topical and intravenous amphotericin B. J Laryngol Otol. 2011; 125:807-10

Payne SJ, Mitzner R, Kunchala S, Roland L, McGinn JD. Acute invasive fungal rhinosinusitis: a 15-Year experience with 41 patients. Otolaryngol Head Neck Surg. 2016; 154:759-64

Patel A, Kaur H, Xess L, Michael JS, Savio J, Rudramurthy S, et al. A multicentre observational study on the epidemiology, risk factors, management and outcomes of Mucormycosis in India. Clin Microbiol Infect. 2020; 26:944.e9 15. doi: 10.1016/j.cmi.2019.11.021

Nithyanandam S, Jacob MS, Battu RR, Thomas RK, Correa MA, D’Souza O. Rhino orbito cerebral Mucormycosis. A retrospective analysis of clinical features and treatment outcomes. Indian J Ophthalmol. 2003; 51:231 6.

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