Role of Inflammatory Markers as Prognostic Indicators in Treatment of Mucormycosis

Main Article Content

Pruthvi RajS
Ashwini Godse
Architha Menon P
Deepika T M
Ravishankar C

Abstract

Introduction: Mucormycosis is opportunistic fungal infection characterized by extensive inflammation, necrosis and infarction of the involved tissues. It is associated with rise in levels of inflammatory markers [Erythrocyte sedimentation rate (ESR) , C-reactive protein (CRP)]. This study was done to know the role of ESR, CRP as prognostic indicators in the treatment of covid-19 associated mucormycosis (CAM).

Materials and Methods: : A retrospective descriptive study was conducted between May 2021 and December 2021 at a tertiary centre. 315 patients with post-covid ROCM (Rhino-orbito-cerebral mucormycosis) were included in study. ESR and CRP were sent for all patients at the time of admission. Postoperatively the same were  repeated on post-op (POD) day 7, day 14, and day 30 during follow-up.


Results: 243 (77.14%) patients were male and 72 (22.86%) were female. 6 patients with stage IV ROCM had recurrence of the disease in the postoperative period. Mean  ESR values in these patients at the time of admission, POD-7, 14, 30 were 98.17, 68.17, 44.00, 80.33 respectively. Mean CRP values in these patients at the time of admission, POD-7, 14, 30 were 58.50, 48.17, 26.33,37.83 respectively.


Conclusion: Serial measurements of inflammatory markers (ESR, CRP) levels helps in the diagnosis and prognostication of  ROCM along with clinical evaluation and imaging.

Article Details

How to Cite
1.
RajS P, Godse A, Menon P A, T M D, C R. Role of Inflammatory Markers as Prognostic Indicators in Treatment of Mucormycosis . BJOHNS [Internet]. 2023Mar.31 [cited 2024Dec.22];30(2):227-32. Available from: https://bjohns.in/journal3/index.php/bjohns/article/view/760
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Main article
Author Biographies

Pruthvi RajS, Shri Atal Bihari Vajpayee Medical College & Research Institute

Assistant Professor, Department of Otorhinolaryngology, 

Ashwini Godse, Bangalore Medical College and Research Institute, Bangalore

Assistant Professor, Department of Otorhinolaryngology, 

Architha Menon P, Shri Atal Bihari Vajpayee Medical College and Research Institute, Bangalore.

Assistant Professor, Department of Otorhinolaryngology, 

Deepika T M, Bangalore Medical College and Research Institute, Bangalore.

Junior Resident, Department of Otorhinolaryngology, 

Ravishankar C, Bangalore Medical College and Research Institute, Bangalore

Professor, Department of Otorhinolaryngology, 

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