Late Oesteoradionecrosis of Mandible Five Years after Radiotherapy for Carcinoma Base of Tongue

Main Article Content

Somesh Mozumder
Shirish Dubey
Aniruddha Dam
Anup Kumar Bhowmick

Abstract

Introduction


Osteoradionecrosis (ORN) is a process where irradiated bone undergoes necrosis and becomes exposed through soft-tissue. It is a late effect of radiotherapy. Early presentation within 2 years, is thought to be related to high dose of Radiation therapy, whereas late presentation is usually secondary to trauma and delayed wound healing with in compromised tissue.


We present a case of late presentation where there was no history of trauma to the associated region; therefore making the case unique.


Case report                                             


50 years old male patient from rural Bengal presented with history of invasive squamous cell carcinoma (SCC) of right base tongue with bilateral cervical nodal metastasis treated with external beam radiotherapy of 70 Gy in 35 fractions in 2009. In April 2014 he developed pain in the right side of lower jaw with foul breath and progressive difficulty and pain while opening mouth. Biopsy established the diagnosis of oesteoradionecrosis.


Discussion


ORN can be spontaneous, but most commonly results from tissue injury. The absence of reserve reparative capacity is a result of the prior radiation injury. The irradiated mandible, periosteum, and overlying soft tissue undergo hyperemia, inflammation, and endarteritis.


Conclusion


During follow up any lesion suspicious of recurrence or second malignancy with clinical features of pain, swelling, trismus, halitosis, mucosal ulceration, bare bone etc a differential diagnosis of oesteoradionecrosis should be kept in mind, even long time after radiotherapy & absence of trauma.

Article Details

How to Cite
1.
Mozumder S, Dubey S, Dam A, Bhowmick AK. Late Oesteoradionecrosis of Mandible Five Years after Radiotherapy for Carcinoma Base of Tongue. BJOHNS [Internet]. 2020Jul.27 [cited 2024Nov.5];26(2):137-40. Available from: https://bjohns.in/journal3/index.php/bjohns/article/view/196
Section
Case report
Author Biographies

Somesh Mozumder, Chittaranjan National Cancer Institute, Kolkata

Senior Resident

Dept. of E.N.T & Head & Neck oncology

Shirish Dubey, Chittaranjan National Cancer Institute, Kolkata

Ex- clinical fellow

Dept. of E.N.T & Head & Neck oncology

Aniruddha Dam, CHITTARANJAN NATIONAL CANCER INSTITUTE. KOLKATA

H.O.D & Specialist grade-1

Dept. of E.N.T & Head & Neck oncology

Anup Kumar Bhowmick, CHITTARANJAN NATIONAL CANCER INSTITUTE. KOLKATA

Specialist grade-1

Dept. of E.N.T & Head & Neck oncology

References

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Kahenasa N, Sung EC, Nabili V, Kelly J, Garrett N, Nishimura I. Resolution of pain and complete healing of mandibular osteoradionecrosis using pentoxifylline and tocopherol: A case report. Oral Surg Oral Med Oral Pathol Oral Radiol, 2012;113:e18-23

Rayatt SS, Mureau MA, Hofer SO. Osteoradionecrosis of mandible: Etiology, prevention, diagnosis and treatment. Indian J Plast Surg. 2007; 40:s65-71

Bras J, de Jonge HK, van Merkesteyn JP. Osteoradionecrosis of the mandible: Pathogenesis. Am J Otolaryngol. 1990; 11:244-50

Jacobson AS, Buchbinder D, Hu K, Urken ML. Paradigm shifts in the management of osteoradionecrosis of the mandible. Oral Oncol, 2010;46:795-801.

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