Vitamin D: A Silent Cofactor for Allergic Rhinitis
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Abstract
Introduction
Allergic rhinitis affects around 50% of atopies in India. Vitamin D is related to both humoral and cell mediated immunity and its receptors are found in inflammatory mediators. This study was conducted to assess any possible association between Allergic rhinitis and serum Vitamin D.
Materials and Methods
A cross sectional study was conducted amongst 41patients with Allergic rhinitis as per ARIA guidelines attending the Otolaryngology outpatient Department of a peripheral tertiary care hospital. Vitamin D levels were assessed in patients with allergic rhinitis in terms of serum Ig-E level and absolute blood eosinophil count (ABEC).
Results
Among 41 patients, 31 patients (75.6%) had deficiency of vitamin D with mean Vitamin D level of 14.87±1.56ng/ml (normal vitamin D level-30-100ng/ml and low <20ng/ml), mean serum Ig-E level was 1040±303.83Iu/ml (normal-1.90-170 IU/ml by CLIA method) and mean ABEC 1226.77±397.89 (normal-30-350/ml).
Conclusion
Low serum Vitamin D is common in Allergic rhinitis patients. Low serum Vitamin D seems to be a significant cofactor in aetiopathogenesis of Allergic rhinitis in most of the cases.
Article Details
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References
Skoner DP. Allergic rhinitis: Definition, epidemiology, pathophysiology, detection, and diagnosis. J Allergy Clin Immunol. 2001 Jul;108(1 Suppl):S2-8
Bachert C. Persistent Rhinitis – Allergy or Non-allergy? Allergy. 2004; 59 Suppl 76:11-5; discussion 15
Holick MF. Vitamin D deficiency. N Engl J Med. 2007; 357:266-81
Hewison M. Vitamin D and Innate and Adaptive immunity. Vitam Horm. 2011; 86:23-62
Ross AC, Manson JE, Abrams SA, Aloia JF, et al. The 2011 report on diatery reference intake for calcium and Vitamin D from Institute of Medicine; what clinicians need to know. J Clin Endocrinol Metab. 2011 Jan; 96(1):53-8
Sadeghi K, Wessner B, Laggner U, Ploder M, et al. Vitamin D down regulates Monocyte TLR expression and triggers hypo responsiveness to pathogen associated molecular pattern. Eur J Immunol. 2006 Feb; 36(2):361-70
Wittig HJ, Belloit J, De Fillippi I, Royal G. Age-related serum immunoglobulin E levels in healthy subjects and in patients with allergic disease. J Allergy Clin Immunol. 1980 Oct; 66(4):305-13
Arshi S, Ghalehbaghi B, Kamrava SK, Aminlou M. Vitamin D serum levels in Allergic rhinitis: any difference from normal population? Asia Pac Allergy 2012 Jan; 2(1):45-8
Modh D, Katarkar A, Thakkar B, Jain A, et al. Role of vitamin D supplementation in allergic rhinitis. Indian Journal of Allergy, Asthma and Immunology 2014; 28(1):35-9
Halonen M, Barbee RA, Lebowitz MD, Burrows B. An epidemiologic study of the interrelationships of total serum immunoglobulin E, allergy skin-test reactivity, and Eosinophilia. The Journal of allergy and clinical immunology1982; 69(2):221-8
Kose S, Senger SS, Yalcin AD, Serin BG, Cavdar G. Vitamin D serum levels in allergic rhinitis.. World Allergy Organization Journal 2015; 8:579
Jung JW, Kim JY, Cho SH, Choi BW, Min KU, Kang HR. Allergic rhinitis and serum 25-hydroxyvitamin D level in Korean adults. Ann Allergy Asthma Immunol. 2013 Nov; 111(5):352-7
Ghaffari J, Ranjbar A, Quade A. Vitamin D Deficiency and Allergic Rhinitis in Children: A Narrative Review. J Pediatr Rev. 2015; 3(2):e2623
Cheng HM, Kim S, Park GH, Chang SE, Bang S, Won CH, Lee MW, Choi JH, Moon KC. Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population. J Allergy Clin Immunol. 2014 Apr;133(4):1048-55
Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C. Vitamin D: Modulator of the immune system. Curr Opin Pharmacol. 2010 Aug; 10(4):482-96
Akbar NA, Zacharek MA. Vitamin D: immunomodulation of asthma, allergic rhinitis, and chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg. 2011 Jun;19(3):224-8
Wjst M, Dold S. Genes, factor X, and allergens: What causes allergic diseases? Allergy 1999; 54(7):757‑9
Campbell GR, Spector SA. Hormonally active vitamin D3 (1alpha,25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection. J Biol Chem. 2011 May 27; 286(21):18890-902
Schauber J, Dorschner RA, Yamasaki K, Brouha B, Gallo RL. Control of the innate epithelial antimicrobial response is cell-type specific and dependent on relevant microenvironmental stimuli. Immunology 2006 Aug;118(4):509-19
Gorman S, Judge MA, Hart PH. Immune-modifying properties of topical vitamin D: Focus on dendritic cells and T cells. J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):247-9
Khoo AL, Chai LY, Koenen HJ, Sweep FC, Joosten I, Netea MG, van der Ven AJ. Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals. Clin Exp Immunol. 2011 Apr;164(1):72-9
Muthian G, Raikwar HP, Rajasingh J, Bright JJ. 1,25 Dihydroxyvitamin-D3 modulates JAK-STAT pathway in IL-12/IFNgamma axis leading to Th1 response in experimental allergic encephalomyelitis. J Neurosci Res. 2006 May 15; 83(7):1299-309
Robinson DS. Regulatory T cells and asthma. Clin Exp Allergy. 2009 Sep;39(9):1314-23
Hartmann B, Heine G, Babina M, Steinmeyer A, et al. Targeting the vitamin D receptor inhibits the B cell-dependent allergic immune response. Allergy 2011 Apr;66(4):540-8
Biggs L, Yu C, Fedoric B, Lopez AF, Galli SJ, Grimbaldeston MA. Evidence that vitamin D(3) promotes mast cell-dependent reduction of chronic UVB-induced skin pathology in mice. J Exp Med. 2010 Mar 15; 207(3):455-63
Gorman S1, Judge MA, Burchell JT, Turner DJ, Hart PH. 1,25-dihydroxyvitamin D3 enhances the ability of transferred CD4+ CD25+ cells to modulate T helper type 2-driven asthmatic responses. Immunology 2010 Jun;130(2):181-92.