Assessing Smell Alteration as Clinical Feature of COVID-19: A Descriptive Study in a Rural Based Tertiary Care COVID Hospital
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Abstract
Introduction
COVID-19 is an ongoing viral pandemic and a very contagious disease. Other than common symptoms like fever, cough and malaise; alteration in smell and taste perception may be the presenting symptoms in a significant number of patients infected with COVID-19.
Materials and Methods
Presence of smell alteration assessed among 150 mild to moderate COVID-19 positive patients admitted at our COVID hospital as well as 150 COVID-19 negative patients in May-June, 2021. Use and throw smell cards were used to detect smell alteration for all. Symptom onset and its resolution were noted. Smell alteration was also evaluated in different age group and gender.
Results
81 (54%) patients among 150 COVID positive cases had smell alteration compared to 9 (6%) patients among non-COVID arm (p value <0.0001). Overall smell alteration was more prevalent among male COVID patients. Hyposmia is more prevalent among younger age group compared to anosmia, which is more among older side. Olfactory dysfunction is seen to be developed at presentation or within 5 days from starting of infection with other symptoms. More than 90% patients regained smell perception within two months post infection.
Conclusion
54% COVID positive patients reported smell loss either at presentation or within 5 days of infection. Using smell cards for smell assessment and being cautious about smell alteration as early symptom helps us to diagnose COVID-19 early.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
References
Guan WJ, Ni ZY, Hu Y Liang Wh, Ou Cq, He Jx. Clinical Characteristics of Corona Virus Disease 2019 in China. N. Engl J Med. 2020; 58(4):711-2. doi:10.1056/NEJMoa2002032
We YC, Chen CS, Chan YJ. Overview of the 2019 Novel Coronavirus (2019-nCoV): The Pathogen of Severe Specific Contagious Pneumonia (SSCP). J Chin Med Assoc. 2020. doi:10.1097/JCMA. 0000000000000270
Saniasiaya J, Islam MA, Abdullah B. Prevalence of Olfactory Dysfunction in Coronavirus Disease 2019 (COVID‐19): A Meta‐analysis of 27,492 Patients. Laryngoscope 2020; 5:10
Hajikhani B, Calcagno T, Nasiri MJ, Jamshidi P, et al. Olfactory and gustatory dysfunction in COVID‐19 patients: A meta‐analysis study. Physiol Rep. 2020; 8(18): e14578
Mercante G, Ferreli F, De Virgilio A, et al. Prevalence of Taste and Smell Dysfunction in Coronavirus Disease 2019. JAMA Otolaryngol Head Neck Surg. 2020; 146(8):723-8
Menni C, Valdes AM, Freidin MB, Ganesh S, et al. Loss of smell and taste in combination with other symptoms is a strong predictor of COVID-19 infection. medRxiv 2020.04.05.20048421
Rajkumar I, Anand KH, Revathishree K, Shoba K, Srinivasan K. Contemporary Analysis of Olfactory Dysfunction in Mild to Moderate COVID 19 Patients in A Tertiary Health Care centre. Indian J Otolaryngol Head Neck Surg. 2020; 30:1-5
Shah NN, Hussain RT, Mustafa H, Mushtaq M, Ali M. Evaluation of Olfactory Acuity in patients with Coronavirus Disease 2019 (COVID-19). Indian J Otolayngol Head Neck Surg. 2020; 27:1-8
Klopfenstein T, Kadiane-Oussou NJ, Toko L, Royer PY, Lepiller Q, Gendrin V, Zayet S. Features of anosmia in COVID-19. Med Mal Infect. 2020; 50(5):436-9
Lovato A, de Filippis C. Clinical Presentation of COVID-19: A Systematic Review Focusing on Upper Airway Symptoms. Ear Nose Throat J. 2020; 99(9):569-576. doi: 10.1177/0145561320920762
Kern RC, Conley DB, Haines GK 3rd, Robinson AM. Pathology of the olfactory mucosa: implications for the treatment of olfactory dysfunction. Laryngoscope. 2004;114(2):279-85. doi: 10.1097/00005537-200402000-00018
Huang C, Wang Y, Li X et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395:497-506
Meng X, Deng Y, Dai Z, Meng Z. COVID-19 and Anosmia: A review based on up-to-date knowledge. Am J Otolatyngol. 2020; 41(5):102581
Mohamed A. Amer, Hossam S. Elherif, Ahmed-Hamid, Saad Elzayat. Early Recovery Pattern of Olfactory disorder in COVID-19 patients; a clinical cohort study. Am J Otolaryngol. 2020; 41(6): 102725
Lee Y, Min P, Lee S, Kim S. Prevalence and duration of acute loss of smell or taste in COVID-19 patients. J Korean Med Sci. 2020;35(18):e174
Santos REA, da Silva MG, do Monte Silva MCB, Barbosa DAM, et al. Onset and duration of symptoms of loss of smell/taste in patients with COVID-19: A systematic review. Am J Otolaryngol. 202; 42(2):102889. doi: 10.1016/j.amjoto.2020.102889.